So who will replace Charlie Sheen on Two And A Half Men? Rob Lowe, John Stamos and even Matt Dillon suggested | Mail Online
I actually saw someone in the comment section of one of these articles with an interesting way to keep the show going.  Apparently the scenario would be that Charlie either dies/goes to rehab and Alan is left in charge of the house.  Judith kicks out Herb (Played by Ryan Stiles of Whose Line is it Anyway Fame) and Herb moves in with Alan.
Personally I think that flat out replacing Sheen's character with another actor would be a huge mistake.  Though Someone like Rob Lowe would certainly make it interesting.  Stamos and Dillon....not so much.